Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3
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چکیده
منابع مشابه
Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3
Activated protein C (APC), a serine protease with anticoagulant and anti-inflammatory activities, exerts direct cytoprotective effects on endothelium via endothelial protein C receptor-dependent activation of protease activated receptor 1 (PAR1). Here, we report that APC protects mouse cortical neurons from two divergent inducers of apoptosis, N-methyl-D-aspartate (NMDA) and staurosporine. APC ...
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1Department of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany; 2Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany; 3Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 4Institute of Pathology, University Hospital, Heidelberg, G...
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ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(04)00019-4